SCHEMBL29964495

SCHEMBL29964495

O=Cc1cc(Br)ccc1OCC1CCOCC1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGDR2 Q9Y5Y4 1/20 0.51
XDH P47989 1/20 0.40
PLA2G1B P04054 1/20 0.39
ATG4B Q9Y4P1 1/20 0.39
DHFR P00374 1/20 0.38
DCPS Q96C86 1/20 0.38
ERN1 O75460 1/20 0.37
TSHR P16473 2/20 0.36
POLB P06746 1/20 0.36
CTDSP1 Q9GZU7 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
ALDH1A1 P00352 1/20 0.36
MAPT P10636 1/20 0.36
HTT P42858 1/20 0.36
HPGD P15428 2/20 0.36
BRD4 O60885 1/20 0.35
CCR5 P51681 1/20 0.35
PIM1 P11309 1/20 0.35
PIM2 Q9P1W9 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27159746 1.00 PTGDR2 (0.51) PTGDR2XDHPLA2G1BATG4BDHFR
SCHEMBL17061451 0.90 PTGDR2 (0.57) PTGDR2PLA2G1BATG4BERN1TSHR
SCHEMBL29964746 0.90 PTGDR2 (0.57) PTGDR2PLA2G1BATG4BERN1TSHR
SCHEMBL5463136 0.87 PTGDR2 (0.55) PTGDR2PLA2G1BATG4BERN1TSHR
SCHEMBL30679664 0.86 PTGDR2 (0.54) PTGDR2PLA2G1BATG4BERN1HPGD
SCHEMBL2424456 0.84 MEN1 (0.45) XDHDHFRDCPSERN1ALDH1A1
SCHEMBL4052501 0.84 PTGDR2 (0.51) PTGDR2PLA2G1BATG4BTDP1PIM1
Hydrochloric Acid SCHEMBL15537884 0.83 PTGDR2 (0.50) PTGDR2PLA2G1BATG4BTDP1PIM1
SCHEMBL21305428 0.79 PTGDR2 (0.49) PTGDR2PLA2G1BATG4BERN1TSHR
SCHEMBL1021560 0.79 PTGDR2 (0.55) PTGDR2PLA2G1BATG4BERN1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117597336-A Halogen substituted amino aza-heteroaryl compounds as inhibitors of hematopoietic progenitor kinase 1 (HPK 1) 安大略省癌症研究所(OICR) 2024-02-23 CN disclosed
WO-2022226668-A1 HALO-SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) 2022-11-03 WO disclosed