Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 18/20 | 1.00 |
| ▸ | PDE7B | Q9NP56 | 2/20 | 0.58 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.51 |
| ▸ | PDE5A | O76074 | 1/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | PDE1A | P54750 | 1/20 | 0.50 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29793337 | 1.00 | PDE7A (1.00) | PDE7APDE7BAKR1B1PDE5APDE4A | |
| SCHEMBL31285823 | 0.84 | PDE7A (0.73) | PDE7APDE7BAKR1B1 | |
| SCHEMBL1743736 | 0.84 | PDE7A (0.73) | PDE7APDE7BAKR1B1 | |
| Hydrochloric Acid SCHEMBL3883238 | 0.83 | PDE7A (0.71) | PDE7APDE7BAKR1B1 | |
| SCHEMBL13880277 | 0.80 | PDE7A (0.67) | PDE7AAKR1B1 | |
| SCHEMBL13068678 | 0.80 | PDE7A (0.67) | PDE7APDE7BAKR1B1 | |
| SCHEMBL9912018 | 0.80 | PDE7A (0.67) | PDE7AAKR1B1PDE1APDE1BPDE4D | |
| SCHEMBL8218955 | 0.80 | PDE7A (0.65) | PDE7A | |
| SCHEMBL13314947 | 0.80 | PDE7A (0.65) | PDE7A | |
| SCHEMBL18490908 | 0.78 | PDE7A (0.64) | PDE7APDE7BAKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2846805-A2 | TREATMENT OF ADDICTION AND IMPULSE-CONTROL DISORDERS USING PDE7 INHIBITORS | Omeros Corporation (US) | 2015-03-18 | — | — | EP | disclosed |
| WO-2013176877-A2 | TREATMENT OF ADDICTION AND IMPULSE-CONTROL DISORDERS USING PDE7 INHIBITORS | OMEROS CORPORATION (US) | 2013-11-28 | — | — | WO | disclosed |
| EP-2640395-A2 | TREATMENT OF ADDICTION AND IMPULSE-CONTROL DISORDERS USING PDE7 INHIBITORS | Omeros Corporation (US) | 2013-09-25 | — | — | EP | disclosed |
| WO-2012064667-A2 | TREATMENT OF ADDICTION AND IMPULSE-CONTROL DISORDERS USING PDE7 INHIBITORS | OMEROS CORPORATION (US) | 2012-05-18 | — | — | WO | disclosed |
| EP-2427193-A1 | USE OF PDE7 INHIBITORS FOR THE TREATMENT OF MOVEMENT DISORDERS | Omeros Corporation (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010129036-A1 | USE OF PDE7 INHIBITORS FOR THE TREATMENT OF MOVEMENT DISORDERS | OMEROS CORPORATION (US) | 2010-11-11 | — | — | WO | disclosed |