Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 10/20 | 0.56 |
| ▸ | PARP11 | Q9NR21 | 9/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | MAPKAPK2 | P49137 | 6/20 | 0.47 |
| ▸ | GRM5 | P41594 | 2/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31079103 | 0.86 | PARP10 (0.55) | PARP10PARP11MAPK1MAPKAPK2GRM5 | |
| SCHEMBL29964432 | 0.84 | PARP10 (0.44) | PARP10PARP11MAPK1GRM5PARP1 | |
| SCHEMBL29914848 | 0.83 | PARP10 (0.52) | PARP10PARP11MAPK1MAPKAPK2GRM5 | |
| SCHEMBL29964097 | 0.83 | MAPK1 (0.53) | PARP10PARP11MAPK1MAPKAPK2GRM5 | |
| SCHEMBL29750194 | 0.80 | PARP11 (0.59) | PARP10PARP11MAPK1MAPKAPK2MAPK9 | |
| SCHEMBL29965164 | 0.78 | PARP10 (0.47) | PARP10PARP11MAPK1MAPKAPK2GRM5 | |
| SCHEMBL29964767 | 0.78 | PARP10 (0.47) | PARP10PARP11MAPK1MAPKAPK2GRM5 | |
| SCHEMBL29964561 | 0.78 | PARP10 (0.52) | PARP10PARP11MAPK1MAPKAPK2GRM5 | |
| SCHEMBL27160022 | 0.77 | PARP10 (0.51) | PARP10PARP11MAPK1MAPKAPK2GRM5 | |
| SCHEMBL27159878 | 0.77 | PARP10 (0.51) | PARP10PARP11MAPK1MAPKAPK2GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022226668-A1 | HALO-SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |