Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 9/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20740744 | 1.00 | KCNH2 (0.48) | KCNH2DRD2DRD3SLC6A4SLC6A2 | |
| SCHEMBL27158028 | 1.00 | KCNH2 (0.48) | KCNH2DRD2DRD3SLC6A4SLC6A2 | |
| SCHEMBL29964787 | 1.00 | KCNH2 (0.48) | KCNH2DRD2DRD3SLC6A4SLC6A2 | |
| SCHEMBL5433122 | 0.84 | KCNH2 (0.49) | KCNH2DRD2DRD3SLC6A4SLC6A2 | |
| SCHEMBL6003999 | 0.84 | KCNH2 (0.49) | KCNH2DRD2DRD3SLC6A4SLC6A2 | |
| SCHEMBL6003376 | 0.84 | KCNH2 (0.49) | KCNH2DRD2DRD3SLC6A4SLC6A2 | |
| SCHEMBL11472691 | 0.83 | KCNH2 (0.51) | KCNH2DRD2DRD3SLC6A4SLC6A2 | |
| Hydrochloric Acid SCHEMBL5440038 | 0.83 | KCNH2 (0.48) | KCNH2DRD2DRD3SLC6A4SLC6A2 | |
| SCHEMBL13823322 | 0.83 | KCNH2 (0.48) | KCNH2DRD2DRD3SLC6A4SLC6A2 | |
| SCHEMBL4076265 | 0.83 | SLC6A4 (0.49) | KCNH2DRD2DRD3SLC6A4SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022226668-A1 | HALO-SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |