SCHEMBL29966809

SCHEMBL29966809

OCc1ccc(-c2noc(C(F)(F)Cl)n2)cc1

nearest known ligand 0.53

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 14/20 0.53
HDAC1 Q13547 9/20 0.53
HDAC8 Q9BY41 9/20 0.53
HDAC4 P56524 6/20 0.51
S1PR1 P21453 4/20 0.49
NOTUM Q6P988 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19463719 0.88 HDAC6 (0.65) HDAC6HDAC1HDAC8HDAC4
SCHEMBL26968035 0.85 HDAC6 (0.48) HDAC6HDAC1HDAC8HDAC4
SCHEMBL29974996 0.85 HDAC6 (0.48) HDAC6HDAC1HDAC8HDAC4NOTUM
Hydrochloric Acid SCHEMBL29975570 0.84 HDAC6 (0.47) HDAC6HDAC1HDAC8HDAC4NOTUM
SCHEMBL26968024 0.80 HDAC4 (0.53) HDAC6HDAC1HDAC4
SCHEMBL26968026 0.79 HDAC1 (0.53) HDAC6HDAC1HDAC8HDAC4
SCHEMBL26968033 0.79 HDAC6 (0.53) HDAC6HDAC1HDAC8HDAC4NOTUM
SCHEMBL29975218 0.78 HDAC6 (0.53) HDAC6HDAC1HDAC8HDAC4
SCHEMBL26968019 0.78 HDAC6 (0.51) HDAC6HDAC1HDAC8HDAC4
SCHEMBL29390471 0.78 HDAC4 (0.57) HDAC6HDAC1HDAC8HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022207494-A1 3-(HETERO)ARYL-5-CHLORODIFLUOROMETHYL-1,2,4-OXADIAZOLE AS FUNGICIDE BAYER AKTIENGESELLSCHAFT (DE) 2022-10-06 WO disclosed
WO-2022207496-A1 3-(HETERO)ARYL-5-CHLORODIFLUOROMETHYL-1,2,4-OXADIAZOLE AS FUNGICIDE BAYER AKTIENGESELLSCHAFT (DE) 2022-10-06 WO disclosed