Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 9/20 | 0.80 |
| ▸ | TNF | P01375 | 8/20 | 0.80 |
| ▸ | MAPK12 | P53778 | 6/20 | 0.80 |
| ▸ | HCK | P08631 | 3/20 | 0.80 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.80 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.80 |
| ▸ | CIT | O14578 | 1/20 | 0.80 |
| ▸ | MUSK | O15146 | 1/20 | 0.80 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.80 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.80 |
| ▸ | STK10 | O94804 | 1/20 | 0.80 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.80 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.80 |
| ▸ | ABL1 | P00519 | 1/20 | 0.80 |
| ▸ | EGFR | P00533 | 1/20 | 0.80 |
| ▸ | RAF1 | P04049 | 1/20 | 0.80 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.80 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.80 |
| ▸ | PRKCB | P05771 | 1/20 | 0.80 |
| ▸ | LCK | P06239 | 1/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29594444 | 1.00 | MAPK14 (0.80) | MAPK14TNFMAPK12HCKMAPK13 | |
| Doramapimod SCHEMBL129721 | 0.89 | MAPK14 (1.00) | MAPK14TNFMAPK12HCKMAPK13 | |
| Doramapimod SCHEMBL29353023 | 0.89 | MAPK14 (1.00) | MAPK14TNFMAPK12HCKMAPK13 | |
| SCHEMBL295388 | 0.89 | MAPK14 (0.78) | MAPK14TNFMAPK12HCKMAPK13 | |
| SCHEMBL29594066 | 0.89 | MAPK14 (0.78) | MAPK14TNFMAPK12HCKMAPK13 | |
| SCHEMBL20876996 | 0.88 | MAPK14 (0.93) | MAPK14TNFMAPK12HCKMAPK13 | |
| Doramapimod SCHEMBL10320344 | 0.88 | MAPK14 (0.98) | MAPK14TNFMAPK12HCKMAPK13 | |
| SCHEMBL294689 | 0.86 | MAPK14 (0.79) | MAPK14TNFMAPK12HCKMAPK13 | |
| SCHEMBL29594339 | 0.86 | MAPK14 (0.79) | MAPK14TNFMAPK12HCKMAPK13 | |
| SCHEMBL296487 | 0.84 | MAPK14 (0.76) | MAPK14TNFMAPK12HCKMAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147104-B1 | AROMATIC HETEROCYCLIC COMPOUNDS AS ANTIINFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMA (US) | 2012-03-14 | — | — | EP | claimed |
| CN-114748622-A | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD | 弗尔康医疗公司 | 2022-07-15 | — | — | CN | disclosed |
| CN-114732910-A | P38 kinase inhibitor reduces DUX4 and downstream gene expression for treatment of FSHD | 弗尔康医疗公司 | 2022-07-12 | — | — | CN | disclosed |
| CN-111601593-B | P38 kinase inhibitor reduces DUX4 and downstream gene expression for treatment of FSHD | 弗尔康医疗公司 | 2022-04-15 | — | — | CN | disclosed |
| CN-111601593-A | P38 kinase inhibitor reduces DUX4 and downstream gene expression for treatment of FSHD | 弗尔康医疗公司 | 2020-08-28 | — | — | CN | disclosed |
| EP-3691620-A1 | P38 KINASE INHIBITORS REDUCE DUX4 AND DOWNSTREAM GENE EXPRESSION FOR THE TREATMENT OF FSHD | Fulcrum Therapeutics, Inc. (US) | 2020-08-12 | — | — | EP | disclosed |
| WO-2019071147-A1 | P38 KINASE INHIBITORS REDUCE DUX4 AND DOWNSTREAM GENE EXPRESSION FOR THE TREATMENT OF FSHD | Fulcrum Therapeutics, Inc. (US) | 2019-04-11 | — | — | WO | disclosed |
| EP-1534282-A2 | PHARMACEUTICAL COMPOSITIONS OF ANTICHOLINERGICS AND P38 KINASE INHIBITORS IN THE TREATMENT OF RESPIRATORY DISEASES | Boehringer Ingelheim Pharma GmbH & Co.KG (DE) | 2005-06-01 | — | — | EP | disclosed |
| EP-1530477-A1 | COMBINATION THERAPY WITH p38 MAP KINASE INHIBITORS AND THEIR PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2005-05-18 | — | — | EP | disclosed |
| EP-1496900-A2 | NEW PHARMACEUTICAL COMPOSITIONS BASED ON ANTICHOLINERGICS AND P38 KINASE INHIBITORS | Boehringer Ingelheim Pharma GmbH & Co.KG (DE) | 2005-01-19 | — | — | EP | disclosed |
| WO-2004014387-A1 | COMBINATION THERAPY WITH p38 MAP KINASE INHIBITORS AND THEIR PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2004-02-19 | — | — | WO | disclosed |
| WO-2004004725-A2 | PHARMACEUTICAL COMPOSITIONS OF ANTICHOLINERGICS AND P38 KINASE INHIBITORS IN THE TREATMENT OF RESPIRATORY DISEASES | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-01-15 | — | — | WO | disclosed |
| WO-2003084539-A2 | NEW PHARMACEUTICAL COMPOSITIONS BASED ON ANTICHOLINERGICS AND P38 KINASE INHIBITORS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2003-10-16 | — | — | WO | disclosed |