Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR2E1 | Q9Y466 | 6/20 | 0.53 |
| ▸ | DDR1 | Q08345 | 8/20 | 0.51 |
| ▸ | DDR2 | Q16832 | 5/20 | 0.51 |
| ▸ | NTRK3 | Q16288 | 4/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.51 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.51 |
| ▸ | ABL1 | P00519 | 4/20 | 0.50 |
| ▸ | KIT | P10721 | 2/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.50 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.49 |
| ▸ | LDLR | P01130 | 1/20 | 0.49 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.49 |
| ▸ | BCR | P11274 | 3/20 | 0.47 |
| ▸ | MUSK | O15146 | 1/20 | 0.47 |
| ▸ | CDK11B | P21127 | 1/20 | 0.47 |
| ▸ | EPHA8 | P29322 | 1/20 | 0.47 |
| ▸ | CDK11A | Q9UQ88 | 1/20 | 0.47 |
| ▸ | RAF1 | P04049 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 1/20 | 0.47 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27081785 | 1.00 | NR2E1 (0.53) | NR2E1DDR1DDR2NTRK3NTRK1 | |
| SCHEMBL27083082 | 0.87 | ABL1 (0.54) | NR2E1DDR1DDR2NTRK3NTRK1 | |
| SCHEMBL29967647 | 0.87 | ABL1 (0.54) | NR2E1DDR1DDR2NTRK3NTRK1 | |
| SCHEMBL29967557 | 0.86 | MAPT (0.44) | DDR1DDR2NTRK3NTRK1NTRK2 | |
| SCHEMBL27083027 | 0.86 | MAPT (0.44) | DDR1DDR2NTRK3NTRK1NTRK2 | |
| SCHEMBL29939696 | 0.86 | DDR1 (0.65) | NR2E1DDR1DDR2NTRK3NTRK1 | |
| SCHEMBL27082304 | 0.86 | DDR1 (0.65) | NR2E1DDR1DDR2NTRK3NTRK1 | |
| SCHEMBL27081687 | 0.84 | DDR1 (0.54) | NR2E1DDR1DDR2NTRK3NTRK1 | |
| SCHEMBL29940107 | 0.84 | NR2E1 (0.54) | NR2E1DDR1DDR2NTRK3NTRK1 | |
| SCHEMBL27082369 | 0.84 | NR2E1 (0.54) | NR2E1DDR1DDR2NTRK3NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4313972-B1 | INDOLINE DERIVATIVES AS DDRS INHIBITORS | CHIESI FARM SPA (IT) | 2025-01-29 | — | — | EP | claimed |
| EP-4313972-A1 | INDOLINE DERIVATIVES AS DDRS INHIBITORS | Chiesi Farmaceutici S.p.A. (IT) | 2024-02-07 | — | — | EP | claimed |
| CN-117062812-A | Indoline derivatives as DDR inhibitors | 奇斯药制品公司 | 2023-11-14 | — | — | CN | claimed |
| WO-2022200577-A1 | INDOLINE DERIVATIVES AS DDRS INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2022-09-29 | — | — | WO | claimed |
| EP-4313972-B1 | INDOLINE DERIVATIVES AS DDRS INHIBITORS | CHIESI FARM SPA (IT) | 2025-01-29 | — | — | EP | disclosed |
| US-20240217967-A1 | INDOLINE DERIVATIVES AS DDRS INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2024-07-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240217967-A1 | INDOLINE DERIVATIVES AS DDRS INHIBITORS | DDR1, DDR2, DDRGK1 | NR2E1 362/4885DDR1 1/4885DDR2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.