Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 9/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.48 |
| ▸ | PIK3C2A | O00443 | 2/20 | 0.48 |
| ▸ | PIK3C2B | O00750 | 2/20 | 0.48 |
| ▸ | PRKDC | P78527 | 4/20 | 0.47 |
| ▸ | ATM | Q13315 | 4/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 11/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.46 |
| ▸ | SERPINA2 | P20848 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.43 |
| ▸ | TDP2 | O95551 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.42 |
| ▸ | LTK | P29376 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21513255 | 1.00 | MTOR (0.49) | MTORPIK3CAPIK3C2APIK3C2BPRKDC | |
| SCHEMBL29968928 | 0.92 | NPC1 (0.45) | MTORPIK3CAPIK3C2APIK3C2BPRKDC | |
| SCHEMBL21513256 | 0.92 | NPC1 (0.45) | MTORPIK3CAPIK3C2APIK3C2BPRKDC | |
| SCHEMBL21513240 | 0.88 | PRKDC (0.45) | MTORPIK3CAPIK3C2APIK3C2BPRKDC | |
| SCHEMBL21513499 | 0.84 | PRKDC (0.45) | MTORPIK3CAPIK3C2APIK3C2BPRKDC | |
| SCHEMBL29968542 | 0.84 | PRKDC (0.45) | MTORPIK3CAPIK3C2APIK3C2BPRKDC | |
| SCHEMBL29969564 | 0.84 | ATM (0.47) | MTORPIK3CAPRKDCATMPIK3CD | |
| SCHEMBL29969221 | 0.84 | ATM (0.47) | MTORPIK3CAPRKDCATMPIK3CD | |
| SCHEMBL26131176 | 0.84 | ATM (0.47) | MTORPIK3CAPRKDCATMPIK3CD | |
| SCHEMBL21513498 | 0.82 | ATM (0.46) | MTORPIK3CAPRKDCATMPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12187742-B2 | Dual ATM and DNA-PK inhibitors for use in anti-tumor therapy | XRAD THERAPEUTICS, INC. (US) | 2025-01-07 | — | — | US | disclosed |
| US-20220315606-A1 | DUAL ATM AND DNA-PK INHIBITORS FOR USE IN ANTI-TUMOR THERAPY | XRAD HOLDING CAYMAN LIMITED (KY) | 2022-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220315606-A1 | DUAL ATM AND DNA-PK INHIBITORS FOR USE IN ANTI-TUMOR THERAPY | ATM, CHEK2, CHEK1 | MTOR 660/4885PIK3CA 480/4885PIK3C2A 1219/4885 |
| US-12187742-B2 | Dual ATM and DNA-PK inhibitors for use in anti-tumor therapy | ATM, CHEK2, CHEK1 | MTOR 660/4885PIK3CA 480/4885PIK3C2A 1219/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.