Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
| ▸ | MAP3K12 | Q12852 | 13/20 | 0.43 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.41 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.40 |
| ▸ | IDH1 | O75874 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | DLK1 | P80370 | 1/20 | 0.36 |
| ▸ | DRG1 | Q9Y295 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23762975 | 1.00 | JAK2 (0.46) | JAK2TYK2MAP3K12PIK3C3TRPV4 | |
| SCHEMBL18153298 | 0.78 | ABCG2 (0.54) | PIK3C3 | |
| SCHEMBL15205840 | 0.78 | MAP3K12 (0.58) | JAK2TYK2MAP3K12DLK1DRG1 | |
| SCHEMBL8298737 | 0.78 | ABCG2 (0.52) | — | |
| SCHEMBL15535083 | 0.77 | MAP3K12 (0.51) | JAK2TYK2MAP3K12TRPV4IDH1 | |
| SCHEMBL16573749 | 0.75 | MAP3K12 (0.53) | JAK2TYK2MAP3K12DLK1DRG1 | |
| SCHEMBL4595845 | 0.74 | KMT2A (0.48) | JAK2TYK2GRM5 | |
| SCHEMBL15602473 | 0.74 | MAP3K12 (0.53) | JAK2TYK2MAP3K12DLK1DRG1 | |
| SCHEMBL15536418 | 0.73 | MAP3K12 (0.61) | MAP3K12DLK1DRG1 | |
| SCHEMBL15602598 | 0.72 | MAP3K12 (0.65) | JAK2TYK2MAP3K12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115151534-A | Inhibitors of interleukin-1 receptor-related kinase (IRAK)/FMS-like receptor tyrosine kinase (FLT 3), pharmaceutical products thereof, and methods thereof | 南京药石科技股份有限公司 | 2022-10-04 | — | — | CN | disclosed |