Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 18/20 | 0.61 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.49 |
| ▸ | MTOR | P42345 | 2/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | CHUK | O15111 | 1/20 | 0.43 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30012022 | 0.83 | PIK3CA (0.78) | PIK3CAPIK3R1PIK3CDPIK3CBMTOR | |
| SCHEMBL28614234 | 0.83 | PIK3CA (0.78) | PIK3CAPIK3R1PIK3CDPIK3CBMTOR | |
| SCHEMBL28601868 | 0.82 | PIK3CA (0.58) | PIK3CAPIK3R1PIK3CDPIK3CBMTOR | |
| SCHEMBL30011591 | 0.82 | PIK3CA (0.58) | PIK3CAPIK3R1PIK3CDPIK3CBMTOR | |
| SCHEMBL29970182 | 0.79 | PIK3CA (0.71) | PIK3CAPIK3R1PIK3CDPIK3CBMTOR | |
| SCHEMBL29970599 | 0.78 | PIK3CA (0.72) | PIK3CAPIK3R1PIK3CDPIK3CBMTOR | |
| SCHEMBL28608594 | 0.76 | PIK3CA (1.00) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL1309536 | 0.74 | PIK3CA (0.74) | PIK3CAPIK3R1PIK3CDPIK3CBMTOR | |
| SCHEMBL29971047 | 0.73 | PIK3CA (0.55) | PIK3CAPIK3R1PIK3CDPIK3CBMTOR | |
| SCHEMBL30011525 | 0.72 | PIK3CA (0.76) | PIK3CAPIK3R1PIK3CDPIK3CBMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022242321-A1 | PI3Kα SELECTIVE INHIBITOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 中国药科大学 | 2022-11-24 | — | — | WO | disclosed |