Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 18/20 | 0.54 |
| ▸ | JAK2 | O60674 | 13/20 | 0.50 |
| ▸ | JAK1 | P23458 | 11/20 | 0.50 |
| ▸ | BTK | Q06187 | 1/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29971712 | 0.89 | JAK3 (0.49) | JAK3JAK2JAK1BTKTYK2 | |
| SCHEMBL29972559 | 0.82 | JAK3 (0.54) | JAK3JAK2JAK1BTKTYK2 | |
| SCHEMBL29971710 | 0.81 | BTK (0.58) | JAK3JAK2JAK1BTKTYK2 | |
| SCHEMBL29972261 | 0.81 | BTK (0.58) | JAK3JAK2JAK1BTKTYK2 | |
| SCHEMBL2105762 | 0.78 | JAK2 (0.55) | JAK3JAK2JAK1TYK2 | |
| SCHEMBL2104120 | 0.77 | JAK2 (0.58) | JAK3JAK2JAK1TYK2 | |
| SCHEMBL2104114 | 0.77 | JAK2 (0.58) | JAK3JAK2JAK1TYK2 | |
| SCHEMBL29972399 | 0.77 | JAK3 (0.54) | JAK3JAK2JAK1BTKTYK2 | |
| SCHEMBL2104807 | 0.76 | JAK2 (0.57) | JAK3JAK2JAK1TYK2 | |
| SCHEMBL29972143 | 0.75 | JAK3 (0.72) | JAK3JAK2JAK1BTKTYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022199599-A1 | ACRYLOYL-SUBSTITUTED COMPOUND, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND USE THEREOF | 凯复(苏州)生物医药有限公司 | 2022-09-29 | — | — | WO | disclosed |