SCHEMBL2997196

SCHEMBL2997196

CC1(C)C(=O)N(c2ccc(SCCO)c(Cl)c2)C(=O)N1Cc1ccncc1

nearest known ligand 0.54

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
IGF1R P08069 13/20 0.54
TAS2R8 Q9NYW2 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2939662 0.94 IGF1R (0.52) IGF1RTAS2R8
Trifluoroacetic Acid SCHEMBL3728102 0.93 IGF1R (0.55) IGF1R
Trifluoroacetic Acid SCHEMBL3730599 0.88 IGF1R (0.53) IGF1R
SCHEMBL3077947 0.87 IGF1R (0.53) IGF1RTAS2R8
SCHEMBL2941557 0.87 IGF1R (0.51) IGF1RTAS2R8
SCHEMBL2942354 0.86 IGF1R (0.59) IGF1RTAS2R8
SCHEMBL2941194 0.85 IGF1R (0.53) IGF1RTAS2R8
SCHEMBL2939681 0.84 IGF1R (0.48) IGF1RTAS2R8
SCHEMBL3728098 0.84 IGF1R (0.53) IGF1R
SCHEMBL2935389 0.84 IGF1R (0.56) IGF1RTAS2R8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1599464-B1 NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS AVENTIS PHARMA SA (FR) 2010-09-22 EP disclosed