Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.57 |
| ▸ | RAB9A | P51151 | 4/20 | 0.57 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.57 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.54 |
| ▸ | BCHE | P06276 | 1/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1499306 | 1.00 | NPC1 (0.57) | NPC1RAB9AKCNK3KCNK9ALDH1A1 | |
| SCHEMBL1499350 | 0.95 | KMT2A (0.60) | NPC1RAB9AKCNK3KCNK9ALDH1A1 | |
| SCHEMBL12766934 | 0.93 | BCHE (0.63) | NPC1RAB9AKCNK3KCNK9ALDH1A1 | |
| SCHEMBL1499499 | 0.90 | KMT2A (0.66) | NPC1RAB9AKCNK3KCNK9ALDH1A1 | |
| SCHEMBL1499644 | 0.90 | MEN1 (0.52) | NPC1RAB9AKCNK3KCNK9ALDH1A1 | |
| SCHEMBL12767130 | 0.88 | BCHE (0.59) | NPC1RAB9AKCNK3KCNK9ALDH1A1 | |
| SCHEMBL1525896 | 0.85 | MEN1 (0.60) | NPC1RAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL1499416 | 0.83 | KCNK3 (0.54) | KCNK3ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1499490 | 0.83 | KMT2A (0.58) | NPC1RAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL16963599 | 0.82 | TDP1 (0.51) | MEN1KMT2ASMN1; SMN2BCHEMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3536691-B1 | CHEMICAL MOLECULES THAT INHIBIT THE SPLICING MECHANISM FOR TREATING DISEASES RESULTING FROM SPLICING ANOMALIES | CENTRE NAT RECH SCIENT (FR) | 2022-10-05 | — | — | EP | disclosed |