Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.54 |
| ▸ | ALK | Q9UM73 | 10/20 | 0.52 |
| ▸ | INSR | P06213 | 9/20 | 0.52 |
| ▸ | IGF1R | P08069 | 9/20 | 0.52 |
| ▸ | PLK1 | P53350 | 2/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | STK10 | O94804 | 1/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | SLC34A2 | O95436 | 1/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | CD74 | P04233 | 1/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
| ▸ | FES | P07332 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29084169 | 0.93 | EGFR (0.63) | EGFRALKINSRIGF1RPTK2 | |
| SCHEMBL29084044 | 0.88 | EGFR (0.65) | EGFRALKINSRIGF1RPTK2 | |
| SCHEMBL29084065 | 0.86 | EGFR (0.53) | EGFRALKINSRIGF1RPLK1 | |
| SCHEMBL29084133 | 0.86 | EGFR (0.55) | EGFRALKINSRIGF1RPTK2 | |
| SCHEMBL29084115 | 0.83 | ALK (0.66) | EGFRALKINSRIGF1RPLK1 | |
| SCHEMBL29084052 | 0.82 | EGFR (0.61) | EGFRALKINSRIGF1RPTK2 | |
| SCHEMBL29084066 | 0.82 | EGFR (0.55) | EGFRALKINSRIGF1RPLK1 | |
| SCHEMBL29083964 | 0.81 | EGFR (0.53) | EGFRALKINSRIGF1R | |
| SCHEMBL29083941 | 0.81 | EGFR (0.55) | EGFRALKINSRIGF1RPLK1 | |
| SCHEMBL29974686 | 0.81 | EGFR (0.52) | EGFRALKINSRIGF1RFGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022206797-A1 | EGFR INHIBITOR, AND COMPOSITION AND USE THEREOF | 贝达药业股份有限公司 | 2022-10-06 | — | — | WO | claimed |
| WO-2022206797-A1 | EGFR INHIBITOR, AND COMPOSITION AND USE THEREOF | 贝达药业股份有限公司 | 2022-10-06 | — | — | WO | disclosed |