Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 15/20 | 0.47 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23754277 | 1.00 | KLKB1 (0.47) | KLKB1GRM2ENPP2NPC1RAB9A | |
| SCHEMBL23754279 | 0.93 | KLKB1 (0.46) | KLKB1GRM2ENPP2NPC1RAB9A | |
| SCHEMBL30027483 | 0.93 | KLKB1 (0.46) | KLKB1GRM2ENPP2NPC1RAB9A | |
| SCHEMBL23768925 | 0.89 | KLKB1 (0.48) | KLKB1GRM2ENPP2NPC1RAB9A | |
| SCHEMBL23753974 | 0.88 | KLKB1 (0.47) | KLKB1GRM2ENPP2NPC1RAB9A | |
| SCHEMBL29906636 | 0.88 | KLKB1 (0.47) | KLKB1GRM2ENPP2NPC1RAB9A | |
| SCHEMBL23769152 | 0.88 | KLKB1 (0.49) | KLKB1GRM2ENPP2 | |
| SCHEMBL23769153 | 0.88 | KLKB1 (0.47) | KLKB1GRM2ENPP2NPC1RAB9A | |
| SCHEMBL23769300 | 0.88 | KLKB1 (0.47) | KLKB1GRM2ENPP2NPC1RAB9A | |
| SCHEMBL29976929 | 0.88 | KLKB1 (0.47) | KLKB1GRM2ENPP2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115087652-B | Heteroaromatic carboxamide derivatives as inhibitors of plasma kallikrein | 勃林格殷格翰国际有限公司 | 2024-05-07 | — | — | CN | disclosed |
| CN-115087652-A | Heteroaromatic carboxamide derivatives as plasma kallikrein inhibitors | 勃林格殷格翰国际有限公司 | 2022-09-20 | — | — | CN | disclosed |