Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 10/20 | 0.59 |
| ▸ | CRBN | Q96SW2 | 10/20 | 0.59 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | CCNC | P24863 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29279158 | 0.88 | DDB1 (0.53) | DDB1CRBNHSD11B1PDE4B | |
| SCHEMBL29279129 | 0.88 | DDB1 (0.53) | DDB1CRBNHSD11B1PDE4B | |
| SCHEMBL29279138 | 0.88 | DDB1 (0.53) | DDB1CRBNHSD11B1PDE4B | |
| SCHEMBL23538385 | 0.87 | DDB1 (0.55) | DDB1CRBN | |
| SCHEMBL30999012 | 0.86 | DDB1 (0.58) | DDB1CRBNHDAC4PDE4B | |
| SCHEMBL29977053 | 0.86 | DDB1 (0.53) | DDB1CRBN | |
| SCHEMBL30258353 | 0.85 | DDB1 (0.55) | DDB1CRBN | |
| SCHEMBL23538345 | 0.84 | DDB1 (0.58) | DDB1CRBN | |
| SCHEMBL23538826 | 0.84 | DDB1 (0.55) | DDB1CRBN | |
| SCHEMBL23538562 | 0.84 | DDB1 (0.55) | DDB1CRBNPDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4333899-A1 | COMPOUNDS FOR TARGETING DEGRADATION OF BRUTON'S TYROSINE KINASE | Biogen MA Inc. (US) | 2024-03-13 | — | — | EP | disclosed |
| WO-2022235945-A1 | COMPOUNDS FOR TARGETING DEGRADATION OF BRUTON'S TYROSINE KINASE | BIOGEN MA INC. (US) | 2022-11-10 | — | — | WO | disclosed |