Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK1 | P51617 | 16/20 | 0.56 |
| ▸ | IRAK4 | Q9NWZ3 | 12/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24007658 | 0.88 | CLK2 (0.43) | IRAK1IRAK4 | |
| SCHEMBL30274584 | 0.88 | CLK2 (0.43) | IRAK1IRAK4 | |
| SCHEMBL15416440 | 0.81 | IRAK1 (0.55) | IRAK1IRAK4 | |
| SCHEMBL29979766 | 0.79 | IRAK1 (0.44) | IRAK1IRAK4 | |
| SCHEMBL29978662 | 0.79 | CTSA (0.41) | IRAK4 | |
| SCHEMBL15416640 | 0.75 | IRAK1 (0.59) | IRAK1IRAK4 | |
| SCHEMBL30274494 | 0.74 | CLK2 (0.43) | IRAK1IRAK4 | |
| SCHEMBL24008090 | 0.74 | CLK2 (0.43) | IRAK1IRAK4 | |
| SCHEMBL16675749 | 0.74 | PRKCI (0.51) | IRAK1IRAK4 | |
| SCHEMBL15431263 | 0.73 | IRAK1 (0.54) | IRAK1IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022216945-A1 | MACROCYCLIC MCL1 INHIBITORS AND USES THEREOF | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2022-10-13 | — | — | WO | disclosed |