Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 7/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | RPS6KA3 | P51812 | 4/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3000940 | 0.77 | MAPKAPK2 (0.56) | MAPKAPK2MAPK1MAP2K1LMNANAMPT | |
| SCHEMBL3000941 | 0.77 | MAPKAPK2 (0.56) | MAPKAPK2MAPK1MAP2K1LMNANAMPT | |
| SCHEMBL2990814 | 0.75 | MAPKAPK2 (0.60) | MAPKAPK2MAPK1MAP2K1LMNAPDE4A | |
| Hydrochloric Acid SCHEMBL2996814 | 0.75 | MAPKAPK2 (0.59) | MAPKAPK2MAPK1MAP2K1LMNAPDE4A | |
| SCHEMBL2993854 | 0.74 | MAPK1 (0.58) | MAPKAPK2MAPK1MAP2K1LMNAPDE4A | |
| SCHEMBL3001121 | 0.74 | MAPKAPK2 (0.61) | MAPKAPK2MAPK1MAP2K1LMNAPDE4A | |
| SCHEMBL2990184 | 0.73 | BRD3 (0.58) | MAPKAPK2MAPK1MAP2K1LMNAPDE4A | |
| SCHEMBL3005586 | 0.72 | MAPKAPK2 (1.00) | MAPKAPK2MAPK1MAP2K1 | |
| SCHEMBL3004610 | 0.71 | MAPKAPK2 (0.78) | MAPKAPK2MAPK1MAP2K1 | |
| SCHEMBL3004609 | 0.71 | MAPKAPK2 (0.78) | MAPKAPK2MAPK1MAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100190773-A1 | Anti-Cytokine Heterocyclic Compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-07-29 | — | — | US | disclosed |
| US-20060276496-A1 | Anti-Cytokine Heterocyclic Compounds | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2006-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276496-A1 | Anti-Cytokine Heterocyclic Compounds | MAPKAPK2, MAP4K2, MAP3K2 | MAPKAPK2 1/4885MAPK1 33/4885MAP2K1 65/4885 |
| US-20100190773-A1 | Anti-Cytokine Heterocyclic Compounds | MAPKAPK2, MAP4K2, MAP3K2 | MAPKAPK2 1/4885MAPK1 33/4885MAP2K1 65/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.