Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.68 |
| ▸ | AR | P10275 | 1/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 2/20 | 0.40 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | BAZ1A | Q9NRL2 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4481815 | 0.81 | EGFR (1.00) | EGFRARPIK3CDPIK3CAFGFR4 | |
| SCHEMBL24783500 | 0.77 | EGFR (0.69) | EGFRARPIK3CDPIK3CAFGFR4 | |
| SCHEMBL28041954 | 0.77 | EGFR (0.69) | EGFRARPIK3CDPIK3CAFGFR4 | |
| SCHEMBL17198305 | 0.77 | EGFR (0.63) | EGFRARPIK3CDPIK3CAFGFR4 | |
| SCHEMBL16368637 | 0.77 | EGFR (0.68) | EGFRARPIK3CDPIK3CAFGFR4 | |
| SCHEMBL21646348 | 0.77 | EGFR (0.68) | EGFRARPIK3CDPIK3CAFGFR4 | |
| SCHEMBL24782968 | 0.77 | EGFR (0.68) | EGFRARPIK3CDPIK3CAFGFR4 | |
| SCHEMBL23055235 | 0.77 | EGFR (0.68) | EGFRARPIK3CDPIK3CAFGFR4 | |
| Hydrochloric Acid SCHEMBL25267663 | 0.76 | EGFR (0.67) | EGFRARPIK3CDPIK3CAFGFR4 | |
| Benzene SCHEMBL28800798 | 0.75 | EGFR (0.65) | EGFRARPIK3CDPIK3CAFGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7786131-B2 | Anticancer agents; restenosis; atherosclerosis; skin disorders | WARNER-LAMBERT COMPANY (US) | 2010-08-31 | — | — | US | disclosed |
| EP-0892789-B2 | IRREVERSIBLE INHIBITORS OF TYROSINE KINASES | WARNER LAMBERT CO (US) | 2009-11-18 | — | — | EP | disclosed |
| CN-100503580-C | Irreversible inhibitors of tyrosine kinases | WARNER LAMBERT CO (US) | 2009-06-24 | — | — | CN | disclosed |
| CN-1923818-A | Irreversible inhibitors of tyrosine kinases | WARNER LAMBERT CO (US) | 2007-03-07 | — | — | CN | disclosed |
| CN-1495172-A | Irreversible inhibitors of tyrosine kinases | ��ʲ | 2004-05-12 | — | — | CN | disclosed |
| CN-1145614-C | Irreversible inhibitors of tyrosine kinases, their pharmaceutical use and pharmaceutical compositions | ��ʲ | 2004-04-14 | — | — | CN | disclosed |
| US-20030229051-A1 | Irreversible inhibitors of tyrosine kinases | BRIDGES ALEXANDER JAMES (US) | 2003-12-11 | — | — | US | disclosed |
| US-6602863-B1 | Irreversible inhibitors of tyrosine kinases | WARNER-LAMBERT COMPANY | 2003-08-05 | — | — | US | disclosed |
| EP-0892789-B1 | IRREVERSIBLE INHIBITORS OF TYROSINE KINASES | WARNER LAMBERT CO (US) | 2002-02-27 | — | — | EP | disclosed |
| US-6344459-B1 | TREATING CANCER, RESTENOSIS, ATHEROSCLEROSIS, ENDOMETRIOSIS, AND PSORIASIS | WARNER-LAMBERT COMPANY | 2002-02-05 | — | — | US | disclosed |
| CN-1218456-A | Irreversible inhibitors of tyrosine kinases | WARNER LAMBERT CO (US) | 1999-06-02 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030229051-A1 | Irreversible inhibitors of tyrosine kinases | ERBB2, ERBB3, LCK | EGFR 26/4885AR 412/4885PIK3CD 684/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.