Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 10/20 | 0.72 |
| ▸ | KRAS | P01116 | 7/20 | 0.72 |
| ▸ | EGFR | P00533 | 8/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.58 |
| ▸ | HDAC4 | P56524 | 8/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.58 |
| ▸ | HDAC7 | Q8WUI4 | 8/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.58 |
| ▸ | HDAC10 | Q969S8 | 8/20 | 0.58 |
| ▸ | HDAC11 | Q96DB2 | 8/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.58 |
| ▸ | HDAC9 | Q9UKV0 | 8/20 | 0.58 |
| ▸ | HDAC5 | Q9UQL6 | 8/20 | 0.58 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.58 |
| ▸ | KDR | P35968 | 2/20 | 0.50 |
| ▸ | FBP1 | P09467 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27041275 | 1.00 | SOS1 (0.72) | SOS1KRASEGFRHDAC3HDAC4 | |
| SCHEMBL27041257 | 1.00 | SOS1 (0.72) | SOS1KRASEGFRHDAC3HDAC4 | |
| SCHEMBL27041272 | 1.00 | SOS1 (0.72) | SOS1KRASEGFRHDAC3HDAC4 | |
| SCHEMBL29486842 | 1.00 | SOS1 (0.72) | SOS1KRASEGFRHDAC3HDAC4 | |
| SCHEMBL29486831 | 1.00 | SOS1 (0.72) | SOS1KRASEGFRHDAC3HDAC4 | |
| SCHEMBL27041260 | 1.00 | SOS1 (0.72) | SOS1KRASEGFRHDAC3HDAC4 | |
| SCHEMBL27057118 | 0.94 | SOS1 (0.76) | SOS1KRASEGFRHDAC3HDAC4 | |
| SCHEMBL29486867 | 0.93 | SOS1 (0.72) | SOS1KRASEGFRHDAC3HDAC4 | |
| SCHEMBL29486873 | 0.93 | SOS1 (0.72) | SOS1KRASEGFRHDAC3HDAC4 | |
| SCHEMBL27041264 | 0.91 | SOS1 (0.71) | SOS1KRASEGFRHDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022197862-A1 | SOS1 PROTEIN DEGRADERS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS | BIOTHERYX, INC. (US) | 2022-09-22 | — | — | WO | disclosed |