Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 8/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24667364 | 1.00 | HRH3 (0.37) | HRH3PRMT5WDR77MCHR1PDE10A | |
| SCHEMBL24667421 | 0.93 | PRMT5 (0.36) | HRH3PRMT5WDR77MCHR1GRM5 | |
| SCHEMBL29986698 | 0.93 | PRMT5 (0.36) | HRH3PRMT5WDR77MCHR1GRM5 | |
| SCHEMBL29986770 | 0.90 | PRMT5 (0.34) | HRH3PRMT5WDR77MCHR1PDE10A | |
| SCHEMBL29987742 | 0.89 | HRH3 (0.33) | HRH3MCHR1PDE10AGRM5SLC6A3 | |
| SCHEMBL24667443 | 0.89 | HRH3 (0.33) | HRH3MCHR1PDE10AGRM5SLC6A3 | |
| SCHEMBL24667346 | 0.89 | GRM5 (0.42) | HRH3PRMT5WDR77MCHR1PDE10A | |
| SCHEMBL29987375 | 0.89 | GRM5 (0.42) | HRH3PRMT5WDR77MCHR1PDE10A | |
| SCHEMBL24667586 | 0.88 | PRMT5 (0.45) | PRMT5WDR77MCHR1GRM5 | |
| SCHEMBL29986992 | 0.88 | PRMT5 (0.45) | PRMT5WDR77MCHR1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4320114-A1 | ISOINDOLINONE COMPOUNDS AND IMAGING AGENTS FOR IMAGING HUNTINGTIN PROTEIN | CHDI Foundation, Inc. (US) | 2024-02-14 | — | — | EP | disclosed |
| CN-117412960-A | Isoindolinone compounds and imaging agents for imaging huntingtin | CHDI基金会股份有限公司 | 2024-01-16 | — | — | CN | disclosed |
| WO-2022216947-A1 | ISOINDOLINONE COMPOUNDS AND IMAGING AGENTS FOR IMAGING HUNTINGTIN PROTEIN | CHDI FOUNDATION, INC. (US) | 2022-10-13 | — | — | WO | disclosed |