Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 6/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.48 |
| ▸ | PIM1 | P11309 | 3/20 | 0.47 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.46 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17373869 | 0.86 | PIM1 (0.48) | IRAK4MAPTBRPF1PIM1PIM3 | |
| SCHEMBL17383336 | 0.80 | IRAK4 (0.57) | IRAK4 | |
| SCHEMBL17373931 | 0.80 | IRAK4 (0.53) | IRAK4MAPTBRPF1PIM1PIM3 | |
| SCHEMBL17373928 | 0.80 | IRAK4 (0.53) | IRAK4MAPTBRPF1PIM1PIM3 | |
| Hydrochloric Acid SCHEMBL17373942 | 0.80 | IRAK4 (0.56) | IRAK4 | |
| SCHEMBL17373840 | 0.79 | NTRK1 (0.58) | IRAK4MAPTPIM1PIM3NTRK1 | |
| SCHEMBL30659518 | 0.79 | NTRK1 (0.58) | IRAK4MAPTPIM1PIM3NTRK1 | |
| SCHEMBL17373838 | 0.79 | NTRK1 (0.58) | IRAK4MAPTPIM1PIM3NTRK1 | |
| SCHEMBL16898759 | 0.78 | IRAK4 (0.57) | IRAK4 | |
| SCHEMBL16899023 | 0.78 | IRAK4 (0.57) | IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4319750-A1 | COMBINATION THERAPIES FOR THE TREATMENT OF CANCER | Curis, Inc. (US) | 2024-02-14 | — | — | EP | claimed |
| WO-2022216379-A1 | COMBINATION THERAPIES FOR THE TREATMENT OF CANCER | CURIS, INC. (US) | 2022-10-13 | — | — | WO | claimed |