Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 19/20 | 0.68 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | TEC | P42680 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16676769 | 1.00 | BTK (0.68) | BTKCYP2C8KCNH2PRKCQEGFR | |
| SCHEMBL28881829 | 1.00 | BTK (0.68) | BTKCYP2C8KCNH2PRKCQEGFR | |
| SCHEMBL16670514 | 0.88 | BTK (0.67) | BTKCYP2C8KCNH2EGFRTEC | |
| SCHEMBL18068358 | 0.88 | BTK (0.67) | BTKCYP2C8KCNH2EGFRTEC | |
| SCHEMBL16597860 | 0.87 | BTK (0.66) | BTKEGFRTEC | |
| SCHEMBL28881363 | 0.86 | BTK (0.68) | BTKCYP2C8KCNH2EGFRTEC | |
| SCHEMBL20998572 | 0.83 | BTK (0.72) | BTKCYP2C8KCNH2EGFRTEC | |
| SCHEMBL18044941 | 0.83 | BTK (0.50) | BTKCYP2C8KCNH2 | |
| SCHEMBL18044940 | 0.83 | BTK (0.50) | BTKCYP2C8KCNH2 | |
| SCHEMBL16676660 | 0.82 | BTK (0.63) | BTKCYP2C8KCNH2EGFRTEC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115304606-B | Degradation agent for simultaneously targeting BTK and GSPT proteins | 清华大学 | 2024-04-19 | — | — | CN | disclosed |
| CN-115304606-A | Degradation agent for simultaneously targeting BTK and GSPT1 proteins | 清华大学 | 2022-11-08 | — | — | CN | disclosed |