Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.34 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | MELK | Q14680 | 1/20 | 0.33 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24667584 | 1.00 | PIK3CG (0.36) | PIK3CGNPC1PKMRAB9AGPR84 | |
| SCHEMBL24667402 | 0.88 | MCHR1 (0.33) | GPR84GRM5MCHR1PDE10AHRH3 | |
| SCHEMBL29986580 | 0.88 | MCHR1 (0.33) | GPR84GRM5MCHR1PDE10AHRH3 | |
| SCHEMBL29987375 | 0.85 | GRM5 (0.42) | PIK3CGNPC1PKMRAB9AGRM5 | |
| SCHEMBL24667346 | 0.85 | GRM5 (0.42) | PIK3CGNPC1PKMRAB9AGRM5 | |
| SCHEMBL24667650 | 0.83 | PIK3CG (0.39) | PIK3CGGRM5AOC3NR1H4FGFR1 | |
| SCHEMBL29987525 | 0.83 | PIK3CG (0.39) | PIK3CGGRM5AOC3NR1H4FGFR1 | |
| SCHEMBL24667432 | 0.83 | PIK3CG (0.37) | PIK3CGGRM5AOC3NR1H4FGFR1 | |
| SCHEMBL29987232 | 0.83 | PIK3CG (0.37) | PIK3CGGRM5AOC3NR1H4FGFR1 | |
| SCHEMBL24667588 | 0.82 | NPC1 (0.44) | NPC1PKMRAB9APDE10AMELK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4320114-A1 | ISOINDOLINONE COMPOUNDS AND IMAGING AGENTS FOR IMAGING HUNTINGTIN PROTEIN | CHDI Foundation, Inc. (US) | 2024-02-14 | — | — | EP | disclosed |
| CN-117412960-A | Isoindolinone compounds and imaging agents for imaging huntingtin | CHDI基金会股份有限公司 | 2024-01-16 | — | — | CN | disclosed |
| WO-2022216947-A1 | ISOINDOLINONE COMPOUNDS AND IMAGING AGENTS FOR IMAGING HUNTINGTIN PROTEIN | CHDI FOUNDATION, INC. (US) | 2022-10-13 | — | — | WO | disclosed |