Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2488849 | 0.91 | SMN1; SMN2 (0.43) | SMN1; SMN2TP53GAAALDH1A1MAPT | |
| SCHEMBL21877583 | 0.91 | SMN1; SMN2 (0.43) | SMN1; SMN2TP53GAAALDH1A1MAPT | |
| SCHEMBL29987791 | 0.90 | SMN1; SMN2 (0.36) | SMN1; SMN2TP53GAAALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL27885527 | 0.87 | SMN1; SMN2 (0.41) | SMN1; SMN2TP53GAAALDH1A1MAPT | |
| SCHEMBL443195 | 0.79 | GAA (0.37) | SMN1; SMN2TP53GAAALDH1A1MAPT | |
| SCHEMBL28453534 | 0.79 | GAA (0.42) | SMN1; SMN2GAAPOLBGLA | |
| SCHEMBL28453536 | 0.79 | GAA (0.42) | SMN1; SMN2GAAPOLBGLA | |
| SCHEMBL443194 | 0.79 | GAA (0.37) | SMN1; SMN2TP53GAAALDH1A1MAPT | |
| SCHEMBL2588381 | 0.78 | TP53 (0.42) | SMN1; SMN2TP53GAAPOLBSIRT5 | |
| SCHEMBL2588378 | 0.78 | TP53 (0.42) | SMN1; SMN2TP53GAAPOLBSIRT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022212902-A1 | MODULATORS OF INTEGRATED STRESS RESPONSE PATHWAY | ALTOS LABS, INC. (US) | 2022-10-06 | — | — | WO | disclosed |