Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 20/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2734299 | 0.87 | KCNJ1 (0.51) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL2722788 | 0.76 | KCNJ1 (0.58) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL299891 | 0.74 | KCNJ1 (0.48) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL15437662 | 0.73 | KCNJ1 (0.61) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL22606865 | 0.73 | KCNJ1 (0.64) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL15964291 | 0.73 | KCNJ1 (0.61) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL21266072 | 0.72 | KCNJ1 (0.44) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL286712 | 0.72 | KCNJ1 (0.53) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL21266199 | 0.72 | KCNJ1 (0.45) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL29195562 | 0.72 | KCNJ1 (0.44) | KCNJ1KCNH2ACHESSTR1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427444-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | Merck Sharp & Dohme Corp. (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010129379-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME CORP. (US) | 2010-11-11 | — | — | WO | disclosed |