Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 8/20 | 0.63 |
| ▸ | EGFR | P00533 | 1/20 | 0.63 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.63 |
| ▸ | BLK | P51451 | 1/20 | 0.63 |
| ▸ | BMX | P51813 | 1/20 | 0.63 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.63 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.63 |
| ▸ | IGF1R | P08069 | 4/20 | 0.56 |
| ▸ | TNK2 | Q07912 | 7/20 | 0.55 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.49 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29989154 | 0.89 | BTK (0.65) | BTKEGFRERBB2BLKBMX | |
| SCHEMBL29989349 | 0.80 | BTK (0.62) | BTKEGFRERBB2BLKBMX | |
| SCHEMBL21044814 | 0.79 | TNK2 (0.70) | BTKTNK2 | |
| SCHEMBL12903810 | 0.79 | TNK2 (0.70) | BTKTNK2 | |
| SCHEMBL30101135 | 0.78 | FGFR4 (0.58) | BTKEGFRIGF1RTNK2FGFR2 | |
| SCHEMBL29435011 | 0.78 | EGFR (1.00) | BTKEGFRERBB2BLKBMX | |
| SCHEMBL19585961 | 0.78 | EGFR (1.00) | BTKEGFRERBB2BLKBMX | |
| SCHEMBL19095672 | 0.78 | EGFR (1.00) | BTKEGFRERBB2BLKBMX | |
| SCHEMBL19097868 | 0.78 | EGFR (1.00) | BTKEGFRERBB2BLKBMX | |
| SCHEMBL29989777 | 0.77 | TNK2 (0.52) | BTKEGFRERBB2BLKBMX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113493439-B | Substituted acrylamide derivative, composition and application thereof | 深圳市塔吉瑞生物医药有限公司 | 2022-10-14 | — | — | CN | disclosed |