Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT6 | P42226 | 9/20 | 0.55 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.55 |
| ▸ | SYK | P43405 | 1/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.50 |
| ▸ | JAK3 | P52333 | 1/20 | 0.50 |
| ▸ | WEE1 | P30291 | 1/20 | 0.49 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.49 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27087838 | 1.00 | STAT6 (0.55) | STAT6NTRK1SYKFGFR1JAK2 | |
| SCHEMBL27403067 | 0.92 | STAT6 (0.51) | STAT6NTRK1FGFR1JAK3WEE1 | |
| SCHEMBL19203832 | 0.79 | FGFR1 (0.64) | STAT6SYKFGFR1JAK2WEE1 | |
| SCHEMBL27087845 | 0.79 | FGFR1 (0.52) | STAT6NTRK1SYKFGFR1JAK2 | |
| SCHEMBL29989739 | 0.79 | FGFR1 (0.52) | STAT6NTRK1SYKFGFR1JAK2 | |
| SCHEMBL29989861 | 0.78 | FLT3 (0.61) | STAT6SYKFGFR1JAK2 | |
| SCHEMBL27087769 | 0.78 | FLT3 (0.61) | STAT6SYKFGFR1JAK2 | |
| SCHEMBL27403055 | 0.77 | SYK (0.53) | STAT6SYKFGFR1JAK2 | |
| SCHEMBL29989599 | 0.77 | CHEK1 (0.65) | STAT6SYK | |
| SCHEMBL27087801 | 0.77 | CHEK1 (0.65) | STAT6SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4320121-A2 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES AS ULK1/2 INHIBITORS AND THEIR USE THEREOF | LifeArc (GB) | 2024-02-14 | — | — | EP | disclosed |
| WO-2022214869-A2 | ULK1/2 INHIBITORS AND THEIR USE THEREOF | LIFEARC (GB) | 2022-10-13 | — | — | WO | disclosed |