Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | TTK | P33981 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
| ▸ | CCND1 | P24385 | 12/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 11/20 | 0.34 |
| ▸ | CDK2 | P24941 | 11/20 | 0.34 |
| ▸ | CDK6 | Q00534 | 11/20 | 0.34 |
| ▸ | CDK4 | P11802 | 2/20 | 0.32 |
| ▸ | CCND3 | P30281 | 2/20 | 0.32 |
| ▸ | CCND2 | P30279 | 1/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.31 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.31 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.31 |
| ▸ | RB1 | P06400 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25123909 | 1.00 | PIM1 (0.37) | PIM1TTKPIM2CCND1CCNE1 | |
| SCHEMBL5061885 | 0.81 | PIM1 (0.38) | PIM1TTKPIM2CCND1CDK2 | |
| SCHEMBL27362189 | 0.81 | KMT2A (0.40) | PIM1TTKPIM2CCND1CDK4 | |
| SCHEMBL29355878 | 0.81 | PIM1 (0.38) | PIM1TTKPIM2CCND1CDK2 | |
| SCHEMBL31637504 | 0.81 | KMT2A (0.40) | PIM1TTKPIM2CCND1CDK4 | |
| SCHEMBL30872552 | 0.79 | CCND1 (0.39) | CCND1CCNE1CDK2CDK6CDK4 | |
| SCHEMBL25123908 | 0.79 | CCND1 (0.39) | CCND1CCNE1CDK2CDK6CDK4 | |
| SCHEMBL31532061 | 0.78 | PIM1 (0.39) | PIM1TTKPIM2CCND1CDK4 | |
| SCHEMBL25123906 | 0.78 | PIM1 (0.35) | PIM1TTKPIM2CCND1CDK4 | |
| SCHEMBL29991085 | 0.78 | PIM1 (0.35) | PIM1TTKPIM2CCND1CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4572755-A2 | CDK2 DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2025-06-25 | — | — | EP | disclosed |
| EP-4573094-A2 | CDK2 INHIBITORS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2025-06-25 | — | — | EP | disclosed |
| EP-4334307-A1 | CDK2 DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2024-03-13 | — | — | EP | disclosed |
| WO-2024039901-A2 | CDK2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2024-02-22 | — | — | WO | disclosed |
| WO-2024039903-A2 | CDK2 INHIBITORS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2024-02-22 | — | — | WO | disclosed |
| WO-2022236058-A1 | CDK2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2022-11-10 | — | — | WO | disclosed |