Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 12/20 | 0.59 |
| ▸ | CRBN | Q96SW2 | 12/20 | 0.59 |
| ▸ | DRD2 | P14416 | 4/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30392246 | 1.00 | DDB1 (0.59) | DDB1CRBNDRD2SIGMAR1TRIM24 | |
| SCHEMBL29991212 | 1.00 | DDB1 (0.59) | DDB1CRBNDRD2SIGMAR1TRIM24 | |
| SCHEMBL30671561 | 1.00 | DDB1 (0.59) | DDB1CRBNDRD2SIGMAR1TRIM24 | |
| SCHEMBL25123797 | 1.00 | DDB1 (0.59) | DDB1CRBNDRD2SIGMAR1TRIM24 | |
| SCHEMBL25123850 | 1.00 | DDB1 (0.59) | DDB1CRBNDRD2SIGMAR1TRIM24 | |
| SCHEMBL25123421 | 1.00 | DDB1 (0.59) | DDB1CRBNDRD2SIGMAR1TRIM24 | |
| SCHEMBL23842179 | 1.00 | DDB1 (0.59) | DDB1CRBNDRD2SIGMAR1TRIM24 | |
| SCHEMBL23842336 | 1.00 | DDB1 (0.59) | DDB1CRBNDRD2SIGMAR1TRIM24 | |
| SCHEMBL22776515 | 1.00 | DDB1 (0.59) | DDB1CRBNDRD2SIGMAR1TRIM24 | |
| SCHEMBL26101673 | 1.00 | DDB1 (0.59) | DDB1CRBNDRD2SIGMAR1TRIM24 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119013277-A | TYK2 degrading agent and application thereof | 凯麦拉医疗公司 | 2024-11-22 | — | — | CN | disclosed |
| EP-4423086-A1 | TYK2 DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2024-09-04 | — | — | EP | disclosed |
| EP-4334307-A1 | CDK2 DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2024-03-13 | — | — | EP | disclosed |
| WO-2023076161-A1 | TYK2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-05-04 | — | — | WO | disclosed |
| WO-2022236058-A1 | CDK2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2022-11-10 | — | — | WO | disclosed |