SCHEMBL29994646

SCHEMBL29994646

FC(F)(F)c1cnc(OC2CCNC2)c(Cl)c1

nearest known ligand 0.47

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CHEK1 O14757 1/20 0.43
CYP1A2 P05177 1/20 0.42
CYP3A4 P08684 1/20 0.42
CYP2C19 P33261 1/20 0.42
RAB9A P51151 1/20 0.41
CHRNB2 P17787 1/20 0.41
CHRNA4 P43681 1/20 0.41
KMT2A Q03164 1/20 0.41
HPGD P15428 1/20 0.41
PRKCZ Q05513 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23703470 1.00 CHEK1 (0.43) CHEK1CYP1A2CYP3A4CYP2C19RAB9A
SCHEMBL23703471 1.00 CHEK1 (0.43) CHEK1CYP1A2CYP3A4CYP2C19RAB9A
Hydrochloric Acid SCHEMBL23703438 0.99 CHEK1 (0.42) CHEK1CYP1A2CYP3A4CYP2C19RAB9A
Hydrochloric Acid SCHEMBL23703442 0.99 CHEK1 (0.42) CHEK1CYP1A2CYP3A4CYP2C19RAB9A
Trifluoroacetic Acid SCHEMBL23702908 0.92 SMN1; SMN2 (0.43) CYP2C19RAB9AKMT2AHPGD
Trifluoroacetic Acid SCHEMBL29935681 0.92 SMN1; SMN2 (0.43) CYP2C19RAB9AKMT2AHPGD
SCHEMBL26774155 0.80 HTR2C (0.44) CHRNB2CHRNA4PRKCZ
SCHEMBL16771127 0.79 SLC6A4 (0.50) CYP1A2CYP3A4CYP2C19RAB9AKMT2A
SCHEMBL17061860 0.79 SLC6A4 (0.50) CYP1A2CYP3A4CYP2C19RAB9AKMT2A
SCHEMBL17061859 0.79 SLC6A4 (0.50) CYP1A2CYP3A4CYP2C19RAB9AKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118702672-A Compounds and compositions for treating skin disorders 卡玛瑞制药有限公司 2024-09-27 CN disclosed
CN-115335050-B Compounds and compositions for treating skin disorders 卡玛瑞制药有限公司 2024-05-17 CN disclosed
CN-115335050-A Compounds and compositions for treating skin conditions 卡玛瑞制药有限公司 2022-11-11 CN disclosed