Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.61 |
| ▸ | GAA | P10253 | 3/20 | 0.61 |
| ▸ | KDM5A | P29375 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.57 |
| ▸ | HTT | P42858 | 6/20 | 0.57 |
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | CES2 | O00748 | 1/20 | 0.52 |
| ▸ | CES1 | P23141 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | PKM | P14618 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.51 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.51 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23388826 | 1.00 | SMN1; SMN2 (0.61) | SMN1; SMN2GAAKDM5AKDM4EHTT | |
| SCHEMBL1147702 | 0.85 | KDM4E (0.73) | SMN1; SMN2KDM5AKDM4EHTTTLR7 | |
| SCHEMBL18006549 | 0.84 | GAA (0.50) | SMN1; SMN2GAAKDM5AKDM4EHTT | |
| SCHEMBL9384187 | 0.83 | NPC1 (0.72) | SMN1; SMN2GAAKDM4EALDH1A1NPC1 | |
| SCHEMBL13385745 | 0.82 | GAA (0.66) | SMN1; SMN2GAAALDH1A1LMNANPC1 | |
| SCHEMBL28871817 | 0.82 | KDM5A (0.63) | SMN1; SMN2KDM5AKDM4EHTTTLR7 | |
| SCHEMBL376232 | 0.81 | GRM5 (0.78) | SMN1; SMN2GAAKDM5AKDM4EHTT | |
| SCHEMBL4411512 | 0.80 | KDM5A (0.60) | SMN1; SMN2GAAKDM5AKDM4EHTT | |
| SCHEMBL5523952 | 0.79 | GAA (0.65) | SMN1; SMN2GAAKDM4EHTTALDH1A1 | |
| SCHEMBL28871785 | 0.78 | TLR7 (0.56) | SMN1; SMN2GAAKDM5AKDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4061366-A1 | INHIBITORS OF HISTONE DEMETHYLASES (PFI-63 AND PFI-90) FOR THE TREATMENT OF CANCER AND FOR THE INHIBITION OF HISTONE DEMETHYLASE IN CELLS | The United States of America, as represented by the Secretary, Department of Health and Human Services (US) | 2022-09-28 | — | — | EP | disclosed |