Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 6/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.50 |
| ▸ | EIF4A1 | P60842 | 2/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PTGES | O14684 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23590269 | 1.00 | DHODH (0.56) | DHODHKMT2AMEN1ALDH1A1GAA | |
| SCHEMBL23590336 | 0.90 | DHODH (0.57) | DHODHKMT2AMEN1ALDH1A1GAA | |
| SCHEMBL23590253 | 0.89 | DHODH (0.70) | DHODHKMT2AMEN1ALDH1A1GAA | |
| SCHEMBL23590262 | 0.89 | ALOX5AP (0.48) | DHODHKMT2AMEN1ALDH1A1EIF4A1 | |
| SCHEMBL23590281 | 0.89 | DHODH (0.59) | DHODHKMT2AMEN1ALDH1A1GAA | |
| SCHEMBL23590338 | 0.85 | DHODH (0.58) | DHODHKMT2AMEN1ALDH1A1GAA | |
| SCHEMBL26075138 | 0.85 | DHODH (0.41) | DHODHKMT2AMEN1ALDH1A1PLA2G2A | |
| SCHEMBL23590267 | 0.85 | DHODH (0.77) | DHODHKMT2AMEN1ALDH1A1GAA | |
| SCHEMBL26075323 | 0.84 | ESR1 (0.38) | DHODHKMT2AMEN1ALDH1A1PLA2G2A | |
| SCHEMBL23590091 | 0.84 | DHODH (0.60) | DHODHKMT2AMEN1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115361948-A | Methods and compositions for inhibiting dihydroorotate dehydrogenase | 俄亥俄州国家创新基金会 | 2022-11-18 | — | — | CN | disclosed |
| EP-4081215-A1 | METHODS AND COMPOSITIONS FOR INHIBITION OF DIHYDROOROTATE DEHYDROGENASE | Ohio State Innovation Foundation (US) | 2022-11-02 | — | — | EP | disclosed |