Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.45 |
| ▸ | CDK1 | P06493 | 3/20 | 0.45 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.45 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.45 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CLK1 | P49759 | 2/20 | 0.42 |
| ▸ | CLK2 | P49760 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27088883 | 1.00 | NPC1 (0.47) | NPC1CLK4CDK1CCNB2CCNB1 | |
| SCHEMBL29999955 | 0.85 | NPC1 (0.47) | NPC1CLK4CDK1CCNB2CCNB1 | |
| SCHEMBL27089006 | 0.85 | NPC1 (0.47) | NPC1CLK4CDK1CCNB2CCNB1 | |
| SCHEMBL27088659 | 0.83 | CCNE2 (0.46) | NPC1CLK4CDK1CCNB2CCNB1 | |
| SCHEMBL29999499 | 0.82 | NPC1 (0.58) | NPC1CLK4CDK1CCNB2CCNB1 | |
| SCHEMBL29999532 | 0.81 | KDM4E (0.56) | NPC1CLK4CDK1CCNB2CCNB1 | |
| SCHEMBL27089388 | 0.81 | KDM4E (0.56) | NPC1CLK4CDK1CCNB2CCNB1 | |
| SCHEMBL29999474 | 0.78 | NPC1 (0.38) | NPC1CLK4CDK1CCNB2CCNB1 | |
| SCHEMBL27088952 | 0.78 | NPC1 (0.38) | NPC1CLK4CDK1CCNB2CCNB1 | |
| SCHEMBL27033740 | 0.73 | NPC1 (0.57) | NPC1CLK4CDK1CCNB2CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4320132-A1 | OXAZEPINE COMPOUNDS AND USES THEREOF IN THE TREATMENT OF CANCER | Genentech, Inc. (US) | 2024-02-14 | — | — | EP | disclosed |
| WO-2022216762-A1 | OXAZEPINE COMPOUNDS AND USES THEREOF IN THE TREATMENT OF CANCER | GENENTECH, INC. (US) | 2022-10-13 | — | — | WO | disclosed |