Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 6/20 | 0.61 |
| ▸ | FGFR4 | P22455 | 5/20 | 0.59 |
| ▸ | ABL1 | P00519 | 8/20 | 0.58 |
| ▸ | CDK1 | P06493 | 1/20 | 0.57 |
| ▸ | CDK2 | P24941 | 1/20 | 0.57 |
| ▸ | CDK8 | P49336 | 1/20 | 0.57 |
| ▸ | ABL2 | P42684 | 3/20 | 0.54 |
| ▸ | RET | P07949 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | KIT | P10721 | 2/20 | 0.54 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | BRAF | P15056 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27088051 | 1.00 | SRC (0.61) | SRCFGFR4ABL1CDK1CDK2 | |
| SCHEMBL27088041 | 0.86 | FGFR4 (0.69) | SRCFGFR4ABL1CDK1CDK2 | |
| SCHEMBL29998987 | 0.86 | FGFR4 (0.69) | SRCFGFR4ABL1CDK1CDK2 | |
| SCHEMBL24449225 | 0.82 | SRC (0.61) | SRCFGFR4ABL1CDK1CDK2 | |
| SCHEMBL27217711 | 0.82 | SRC (0.59) | SRCFGFR4ABL1CDK1CDK2 | |
| SCHEMBL19322516 | 0.81 | SRC (0.58) | SRCFGFR4ABL1CDK1CDK2 | |
| SCHEMBL20214701 | 0.80 | ABL1 (0.65) | SRCFGFR4ABL1CDK1CDK2 | |
| SCHEMBL24448252 | 0.80 | SRC (0.63) | SRCFGFR4ABL1CDK1CDK2 | |
| SCHEMBL24449086 | 0.79 | SRC (0.62) | SRCFGFR4ABL1CDK1CDK2 | |
| SCHEMBL15778120 | 0.79 | SRC (0.55) | SRCABL1CDK1CDK2CDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4320127-A1 | NEK7 INHIBITORS | Halia Therapeutics, Inc. (US) | 2024-02-14 | — | — | EP | disclosed |
| WO-2022216680-A1 | NEK7 INHIBITORS | Halia Therapeutics, Inc. (US) | 2022-10-13 | — | — | WO | disclosed |