Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 17/20 | 0.65 |
| ▸ | ALB | P02768 | 2/20 | 0.65 |
| ▸ | BCL2 | P10415 | 3/20 | 0.51 |
| ▸ | PMAIP1 | Q13794 | 3/20 | 0.49 |
| ▸ | BAD | Q92934 | 3/20 | 0.47 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24745273 | 1.00 | MCL1 (0.65) | MCL1ALBBCL2PMAIP1BAD | |
| SCHEMBL24745257 | 0.92 | MCL1 (0.67) | MCL1ALBBCL2PMAIP1BAD | |
| SCHEMBL30000916 | 0.92 | MCL1 (0.67) | MCL1ALBBCL2PMAIP1BAD | |
| SCHEMBL30000898 | 0.91 | MCL1 (0.78) | MCL1ALBBCL2PMAIP1BAD | |
| SCHEMBL24745258 | 0.91 | MCL1 (0.78) | MCL1ALBBCL2PMAIP1BAD | |
| SCHEMBL24745169 | 0.86 | MCL1 (0.61) | MCL1BCL2BCL2L1 | |
| SCHEMBL30000751 | 0.86 | MCL1 (0.61) | MCL1BCL2BCL2L1 | |
| SCHEMBL24773111 | 0.84 | MCL1 (0.59) | MCL1ALBBCL2PMAIP1BAD | |
| SCHEMBL24746693 | 0.83 | MCL1 (0.72) | MCL1ALBBCL2PMAIP1BAD | |
| SCHEMBL24745228 | 0.83 | MCL1 (0.66) | MCL1ALBBCL2PMAIP1BAD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022255888-A1 | TARGETED PROTEIN DEGRADATION USING BIFUNCTIONAL COMPOUNDS THAT BIND UBIQUITIN LIGASE AND TARGET MCL-1 PROTEIN | CAPTOR THERAPEUTICS S.A. (PL) | 2022-12-08 | — | — | WO | disclosed |