Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | PRKDC | P78527 | 1/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 3/20 | 0.40 |
| ▸ | MAOA | P21397 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29187041 | 0.89 | POLB (0.41) | POLBNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL29187044 | 0.89 | POLB (0.41) | POLBNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL3075863 | 0.76 | MEN1 (0.47) | SMN1; SMN2ALDH1A1PRKDCLMNA | |
| SCHEMBL29187129 | 0.76 | POLB (0.43) | POLBNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL14645771 | 0.73 | DPP4 (0.57) | HCRTR1HCRTR2CYP3A4 | |
| SCHEMBL14646637 | 0.73 | DPP4 (0.57) | HCRTR1HCRTR2CYP3A4 | |
| SCHEMBL14646652 | 0.71 | MEN1 (0.58) | NPC1RAB9ASMN1; SMN2HCRTR1HCRTR2 | |
| SCHEMBL13139726 | 0.70 | POLB (0.68) | POLBNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL30001499 | 0.69 | POLB (0.51) | POLBNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL29187114 | 0.69 | POLB (0.66) | POLBNPC1RAB9ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4347032-A1 | SUBSTITUTED TETRAHYDROFURAN-2-CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS | Vertex Pharmaceuticals Incorporated (US) | 2024-04-10 | — | — | EP | disclosed |
| WO-2022256702-A1 | SUBSTITUTED TETRAHYDROFURAN-2-CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-12-08 | — | — | WO | disclosed |