Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 15/20 | 0.66 |
| ▸ | ALB | P02768 | 2/20 | 0.66 |
| ▸ | BCL2 | P10415 | 5/20 | 0.49 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.49 |
| ▸ | BAD | Q92934 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | PMAIP1 | Q13794 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4154074 | 1.00 | MCL1 (0.66) | MCL1ALBBCL2BCL2L1BAD | |
| SCHEMBL4165032 | 0.89 | MCL1 (0.52) | MCL1ALBBCL2BCL2L1BAD | |
| SCHEMBL4159851 | 0.87 | MCL1 (0.52) | MCL1ALBBCL2BCL2L1POLB | |
| SCHEMBL24745244 | 0.84 | MCL1 (0.57) | MCL1 | |
| SCHEMBL4175366 | 0.84 | MCL1 (0.49) | MCL1ALBBCL2BCL2L1BAD | |
| SCHEMBL30000916 | 0.84 | MCL1 (0.67) | MCL1ALBBCL2BCL2L1BAD | |
| SCHEMBL24745257 | 0.84 | MCL1 (0.67) | MCL1ALBBCL2BCL2L1BAD | |
| SCHEMBL4173496 | 0.82 | MCL1 (0.48) | MCL1ALBBCL2BCL2L1BAD | |
| SCHEMBL4170698 | 0.79 | MCL1 (1.00) | MCL1ALBBCL2BCL2L1PMAIP1 | |
| SCHEMBL4170176 | 0.79 | MCL1 (0.54) | MCL1ALBBCL2BCL2L1BAD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4347579-A1 | TARGETED PROTEIN DEGRADATION USING BIFUNCTIONAL COMPOUNDS THAT BIND UBIQUITIN LIGASE AND TARGET MCL-1 PROTEIN | Captor Therapeutics S.A. (PL) | 2024-04-10 | — | — | EP | disclosed |
| WO-2022255888-A1 | TARGETED PROTEIN DEGRADATION USING BIFUNCTIONAL COMPOUNDS THAT BIND UBIQUITIN LIGASE AND TARGET MCL-1 PROTEIN | CAPTOR THERAPEUTICS S.A. (PL) | 2022-12-08 | — | — | WO | disclosed |
| WO-2022253713-A1 | TARGETED PROTEIN DEGRADATION USING BIFUNCTIONAL COMPOUNDS THAT BIND UBIQUITIN LIGASE AND TARGET MCL-1 PROTEIN | CAPTOR THERAPEUTICS S.A. (PL) | 2022-12-08 | — | — | WO | disclosed |