Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 19/20 | 0.44 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24693418 | 0.82 | SCN10A (0.42) | SCN10A | |
| SCHEMBL30000608 | 0.82 | BACE1 (0.34) | — | |
| SCHEMBL23483631 | 0.82 | SCN10A (0.42) | SCN10A | |
| SCHEMBL24708361 | 0.74 | FLT3 (0.41) | — | |
| SCHEMBL30000544 | 0.73 | SCN10A (0.41) | SCN10A | |
| SCHEMBL24707105 | 0.72 | RAF1 (0.37) | SCN10ARAF1BRAF | |
| SCHEMBL30001380 | 0.72 | RAF1 (0.37) | SCN10ARAF1BRAF | |
| SCHEMBL24707327 | 0.72 | RAF1 (0.37) | SCN10ARAF1BRAF | |
| SCHEMBL30001997 | 0.72 | RAF1 (0.37) | SCN10ARAF1BRAF | |
| SCHEMBL29186906 | 0.72 | RAF1 (0.37) | SCN10ARAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4347032-A1 | SUBSTITUTED TETRAHYDROFURAN-2-CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS | Vertex Pharmaceuticals Incorporated (US) | 2024-04-10 | — | — | EP | disclosed |
| WO-2022256702-A1 | SUBSTITUTED TETRAHYDROFURAN-2-CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-12-08 | — | — | WO | disclosed |