Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | ECE1 | P42892 | 7/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA6 | P23280 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | TPMT | P51580 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27088325 | 1.00 | KDM4E (0.60) | KDM4EL3MBTL1ECE1MAPK1TSHR | |
| SCHEMBL27088319 | 0.85 | MAPT (0.45) | KDM4EL3MBTL1MAPK1TSHRMAPT | |
| SCHEMBL1105941 | 0.77 | KDM4E (0.43) | KDM4EL3MBTL1TSHRMAPTALOX15 | |
| SCHEMBL7225742 | 0.75 | KDM4E (1.00) | KDM4EL3MBTL1ECE1MAPK1TSHR | |
| SCHEMBL7234015 | 0.75 | KDM4E (0.68) | KDM4EL3MBTL1ECE1MAPK1TSHR | |
| SCHEMBL22234858 | 0.75 | KDM4E (0.43) | KDM4EL3MBTL1TSHRMAPTALOX15 | |
| SCHEMBL13363185 | 0.75 | KDM4E (0.68) | KDM4EL3MBTL1ECE1MAPK1TSHR | |
| SCHEMBL27087492 | 0.75 | KDM4E (0.44) | KDM4EL3MBTL1TSHRMAPTALOX15 | |
| SCHEMBL24554614 | 0.75 | HPGD (0.41) | KDM4EL3MBTL1MAPK1TSHRMAPT | |
| SCHEMBL29682888 | 0.75 | HPGD (0.41) | KDM4EL3MBTL1MAPK1TSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4320111-A1 | HYDROXYPYRIDINE HSD17B13 INHIBITORS AND USES THEREOF | Inipharm, Inc. (US) | 2024-02-14 | — | — | EP | disclosed |
| WO-2022216626-A1 | HYDROXYPYRIDINE HSD17B13 INHIBITORS AND USES THEREOF | INIPHARM, INC. (US) | 2022-10-13 | — | — | WO | disclosed |