Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 8/20 | 0.40 |
| ▸ | NPC1 | O15118 | 6/20 | 0.40 |
| ▸ | RAB9A | P51151 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.38 |
| ▸ | PKM | P14618 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23536431 | 1.00 | SMN1; SMN2 (0.41) | SMN1; SMN2POLBLMNAMAPTNPC1 | |
| SCHEMBL23568017 | 1.00 | SMN1; SMN2 (0.41) | SMN1; SMN2POLBLMNAMAPTNPC1 | |
| SCHEMBL25726483 | 0.89 | MAPT (0.45) | SMN1; SMN2POLBLMNAMAPTNPC1 | |
| SCHEMBL25878447 | 0.89 | MAPT (0.42) | SMN1; SMN2POLBLMNAMAPTNPC1 | |
| SCHEMBL23568604 | 0.88 | IRAK4 (0.41) | SMN1; SMN2POLBLMNAALDH1A1NPSR1 | |
| SCHEMBL23539620 | 0.88 | IRAK4 (0.41) | SMN1; SMN2POLBLMNAALDH1A1NPSR1 | |
| SCHEMBL30409630 | 0.88 | POLB (0.38) | SMN1; SMN2POLBLMNAMAPTALDH1A1 | |
| SCHEMBL23568338 | 0.88 | POLB (0.38) | SMN1; SMN2POLBLMNAMAPTALDH1A1 | |
| SCHEMBL23539319 | 0.88 | POLB (0.38) | SMN1; SMN2POLBLMNAMAPTALDH1A1 | |
| SCHEMBL23536507 | 0.88 | MAPT (0.45) | SMN1; SMN2POLBLMNAMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076524-A2 | IRAK DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |