SCHEMBL30006622

SCHEMBL30006622

CC(=O)Nc1cccc(-c2ccc3ncc(-c4ccccc4)n3c2)c1

nearest known ligand 0.65

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
FYN P06241 16/20 0.65
DYRK3 O43781 1/20 0.55
CCNT1 O60563 1/20 0.55
CCNA2 P20248 1/20 0.55
CDK2 P24941 1/20 0.55
CDK9 P50750 1/20 0.55
CDK5 Q00535 1/20 0.55
DYRK1A Q13627 1/20 0.55
CDK5R1 Q15078 1/20 0.55
DYRK2 Q92630 1/20 0.55
DYRK1B Q9Y463 1/20 0.55
RIPK2 O43353 1/20 0.55
KCNH2 Q12809 1/20 0.54
PIK3CA P42336 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23535614 1.00 FYN (0.65) FYNDYRK3CCNT1CCNA2CDK2
SCHEMBL3323066 0.95 FYN (0.65) FYNDYRK3CCNT1CCNA2CDK2
SCHEMBL3322441 0.87 FYN (0.69) FYNDYRK3CCNT1CCNA2CDK2
SCHEMBL3320098 0.86 FYN (0.53) FYNRIPK2
SCHEMBL13336733 0.86 FYN (0.62) FYNDYRK3CCNT1CCNA2CDK2
SCHEMBL30006113 0.86 FYN (0.55) FYNDYRK3CCNT1CCNA2CDK2
SCHEMBL23535607 0.86 FYN (0.55) FYNDYRK3CCNT1CCNA2CDK2
SCHEMBL3323316 0.85 FYN (0.69) FYNDYRK3CCNT1CCNA2CDK2
SCHEMBL13336737 0.84 FYN (0.71) FYNDYRK3CCNT1CCNA2CDK2
SCHEMBL13336397 0.84 FYN (0.64) FYNDYRK3CCNT1CCNA2CDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120025336-A LIN28 inhibitors and methods of use thereof 加利福尼亚大学董事会 2025-05-23 CN disclosed
CN-115087657-B LIN28 inhibitors and methods of use thereof 加利福尼亚大学董事会 2025-01-21 CN disclosed