SCHEMBL30006727

SCHEMBL30006727

Cc1cc2cc(C(=O)NCC(O)(c3nc(-c4ccc(F)cc4)c(Cl)c(C(C)(C)O)c3F)C(F)(F)F)cc(OC3CC3)c2nn1

nearest known ligand 0.59

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
CFTR P13569 3/20 0.33
AR P10275 1/20 0.30
SSTR5 P35346 1/20 0.30
CYP2C9 P11712 1/20 0.30
MAPK14 Q16539 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25687390 1.00 CFTR (0.33) CFTRARSSTR5CYP2C9MAPK14
SCHEMBL25687387 0.94 CFTR (0.34) CFTRARCYP2C9MAPK14
SCHEMBL25687279 0.92 SSTR5 (0.32) CFTRARSSTR5
SCHEMBL30007076 0.92 SSTR5 (0.32) CFTRARSSTR5
SCHEMBL23958696 0.92 SSTR5 (0.32) CFTRARSSTR5
SCHEMBL30007224 0.91 CFTR (0.36) CFTR
SCHEMBL23958750 0.91 CFTR (0.36) CFTR
SCHEMBL23958781 0.91 CFTR (0.36) CFTR
SCHEMBL25687276 0.86 CFTR (0.34) CFTRARSSTR5CYP2C9MAPK14
SCHEMBL25235693 0.85 CFTR (0.38) CFTR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115461336-A RSV inhibiting 3-substituted quinoline and cinnoline derivatives 爱尔兰詹森科学公司 2022-12-09 CN disclosed