Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 6/20 | 0.82 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 3/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL290562 | 0.92 | PDE5A (0.84) | PDE5APOLBALDH1A1TSHRMAPT | |
| SCHEMBL28565167 | 0.90 | PDE5A (1.00) | PDE5AALDH1A1MAPTKDM4EMEN1 | |
| SCHEMBL29408518 | 0.90 | PDE5A (1.00) | PDE5AALDH1A1MAPTKDM4EMEN1 | |
| SCHEMBL6068236 | 0.85 | PDE5A (0.88) | PDE5APOLBALDH1A1MAPTKDM4E | |
| SCHEMBL290215 | 0.85 | PDE5A (0.73) | PDE5APOLBALDH1A1MAPTKDM4E | |
| SCHEMBL290923 | 0.84 | PDE5A (0.72) | PDE5APOLBMAPTAURKAAURKB | |
| SCHEMBL29408513 | 0.83 | PDE5A (0.84) | PDE5APOLBALDH1A1MAPTKDM4E | |
| SCHEMBL28570865 | 0.83 | PDE5A (0.84) | PDE5APOLBALDH1A1MAPTKDM4E | |
| SCHEMBL290625 | 0.79 | PDE5A (0.65) | PDE5APOLBALDH1A1TSHRMAPT | |
| SCHEMBL290600 | 0.79 | PDE5A (0.64) | PDE5AAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115192711-A | Use of PDE7 inhibitors for the treatment of movement disorders | 奥默罗斯公司 | 2022-10-18 | — | — | CN | disclosed |