Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.69 |
| ▸ | JAK3 | P52333 | 3/20 | 0.69 |
| ▸ | JAK1 | P23458 | 1/20 | 0.69 |
| ▸ | TYK2 | P29597 | 1/20 | 0.69 |
| ▸ | GPR55 | Q9Y2T6 | 8/20 | 0.49 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.42 |
| ▸ | KRAS | P01116 | 1/20 | 0.41 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12141008 | 1.00 | JAK2 (0.69) | JAK2JAK3JAK1TYK2GPR55 | |
| Hydrochloric Acid SCHEMBL14954444 | 0.99 | JAK2 (0.68) | JAK2JAK3JAK1TYK2GPR55 | |
| SCHEMBL30007953 | 0.91 | JAK2 (0.69) | JAK2JAK3JAK1TYK2GPR55 | |
| SCHEMBL12140810 | 0.91 | JAK2 (0.69) | JAK2JAK3JAK1TYK2GPR55 | |
| SCHEMBL30007242 | 0.89 | JAK2 (0.77) | JAK2JAK3JAK1TYK2GPR55 | |
| SCHEMBL1367151 | 0.89 | JAK2 (0.68) | JAK2JAK3JAK1TYK2GPR55 | |
| SCHEMBL1365499 | 0.89 | JAK2 (0.77) | JAK2JAK3JAK1TYK2GPR55 | |
| SCHEMBL14954395 | 0.89 | JAK2 (0.68) | JAK2JAK3JAK1TYK2GPR55 | |
| SCHEMBL15436272 | 0.88 | JAK2 (0.67) | JAK2JAK3JAK1TYK2GPR55 | |
| Hydrochloric Acid SCHEMBL1368811 | 0.88 | JAK2 (0.76) | JAK2JAK3JAK1TYK2GPR55 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023176972-A1 | THERAPEUTIC AGENT FOR HIGH-RISK MYELOFIBROSIS | 日本新薬株式会社 | 2023-09-21 | — | — | WO | claimed |
| WO-2023175932-A1 | THERAPEUTIC AGENT FOR HIGH-RISK MYELOFIBROSIS | 日本新薬株式会社 | 2023-09-21 | — | — | WO | claimed |
| WO-2022239068-A1 | CYTOKINE STORM INHIBITOR | 日本新薬株式会社 | 2022-11-17 | — | — | WO | claimed |
| WO-2023176972-A1 | THERAPEUTIC AGENT FOR HIGH-RISK MYELOFIBROSIS | 日本新薬株式会社 | 2023-09-21 | — | — | WO | disclosed |
| WO-2023175932-A1 | THERAPEUTIC AGENT FOR HIGH-RISK MYELOFIBROSIS | 日本新薬株式会社 | 2023-09-21 | — | — | WO | disclosed |
| WO-2022239068-A1 | CYTOKINE STORM INHIBITOR | 日本新薬株式会社 | 2022-11-17 | — | — | WO | disclosed |