Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.53 |
| ▸ | JAK3 | P52333 | 2/20 | 0.53 |
| ▸ | JAK1 | P23458 | 1/20 | 0.53 |
| ▸ | TYK2 | P29597 | 1/20 | 0.53 |
| ▸ | PRCP | P42785 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 6/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | IDH1 | O75874 | 3/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.38 |
| ▸ | GPR55 | Q9Y2T6 | 3/20 | 0.36 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1365514 | 0.92 | JAK2 (0.55) | JAK2JAK3JAK1TYK2PRCP | |
| SCHEMBL1366456 | 0.89 | JAK2 (0.54) | JAK2JAK3JAK1TYK2PRCP | |
| SCHEMBL1366452 | 0.89 | JAK2 (0.54) | JAK2JAK3JAK1TYK2PRCP | |
| SCHEMBL1367569 | 0.89 | JAK2 (0.54) | JAK2JAK3JAK1TYK2PRCP | |
| SCHEMBL12140791 | 0.88 | JAK2 (0.54) | JAK2JAK3JAK1TYK2PRCP | |
| Hydrochloric Acid SCHEMBL1368652 | 0.88 | JAK2 (0.54) | JAK2JAK3JAK1TYK2PRCP | |
| Hydrochloric Acid SCHEMBL1368656 | 0.88 | JAK2 (0.54) | JAK2JAK3JAK1TYK2PRCP | |
| SCHEMBL1367477 | 0.88 | JAK2 (0.53) | JAK2JAK3JAK1TYK2PRCP | |
| SCHEMBL1367022 | 0.88 | JAK2 (0.53) | JAK2JAK3JAK1TYK2PRCP | |
| SCHEMBL1367478 | 0.88 | JAK2 (0.53) | JAK2JAK3JAK1TYK2PRCP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023176972-A1 | THERAPEUTIC AGENT FOR HIGH-RISK MYELOFIBROSIS | 日本新薬株式会社 | 2023-09-21 | — | — | WO | claimed |
| WO-2023175932-A1 | THERAPEUTIC AGENT FOR HIGH-RISK MYELOFIBROSIS | 日本新薬株式会社 | 2023-09-21 | — | — | WO | claimed |
| WO-2022239068-A1 | CYTOKINE STORM INHIBITOR | 日本新薬株式会社 | 2022-11-17 | — | — | WO | claimed |
| WO-2023176972-A1 | THERAPEUTIC AGENT FOR HIGH-RISK MYELOFIBROSIS | 日本新薬株式会社 | 2023-09-21 | — | — | WO | disclosed |
| WO-2023175932-A1 | THERAPEUTIC AGENT FOR HIGH-RISK MYELOFIBROSIS | 日本新薬株式会社 | 2023-09-21 | — | — | WO | disclosed |
| WO-2022239068-A1 | CYTOKINE STORM INHIBITOR | 日本新薬株式会社 | 2022-11-17 | — | — | WO | disclosed |