Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.66 |
| ▸ | JAK3 | P52333 | 4/20 | 0.66 |
| ▸ | JAK1 | P23458 | 1/20 | 0.66 |
| ▸ | TYK2 | P29597 | 1/20 | 0.66 |
| ▸ | GPR55 | Q9Y2T6 | 13/20 | 0.44 |
| ▸ | PLK1 | P53350 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1366352 | 1.00 | JAK2 (0.66) | JAK2JAK3JAK1TYK2GPR55 | |
| Hydrochloric Acid SCHEMBL1368758 | 0.99 | JAK2 (0.65) | JAK2JAK3JAK1TYK2GPR55 | |
| SCHEMBL1365990 | 0.92 | JAK2 (0.64) | JAK2JAK3JAK1TYK2GPR55 | |
| SCHEMBL1365991 | 0.92 | JAK2 (0.64) | JAK2JAK3JAK1TYK2GPR55 | |
| Hydrochloric Acid SCHEMBL1369208 | 0.91 | JAK2 (0.62) | JAK2JAK3JAK1TYK2GPR55 | |
| SCHEMBL1366824 | 0.91 | JAK2 (0.62) | JAK2JAK3JAK1TYK2GPR55 | |
| Hydrochloric Acid SCHEMBL1369212 | 0.91 | JAK2 (0.62) | JAK2JAK3JAK1TYK2GPR55 | |
| SCHEMBL1366826 | 0.91 | JAK2 (0.62) | JAK2JAK3JAK1TYK2GPR55 | |
| SCHEMBL12140834 | 0.91 | JAK2 (0.60) | JAK2JAK3JAK1TYK2GPR55 | |
| SCHEMBL30007104 | 0.91 | JAK2 (0.60) | JAK2JAK3JAK1TYK2GPR55 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023176972-A1 | THERAPEUTIC AGENT FOR HIGH-RISK MYELOFIBROSIS | 日本新薬株式会社 | 2023-09-21 | — | — | WO | claimed |
| WO-2023175932-A1 | THERAPEUTIC AGENT FOR HIGH-RISK MYELOFIBROSIS | 日本新薬株式会社 | 2023-09-21 | — | — | WO | claimed |
| WO-2022239068-A1 | CYTOKINE STORM INHIBITOR | 日本新薬株式会社 | 2022-11-17 | — | — | WO | claimed |
| WO-2023176972-A1 | THERAPEUTIC AGENT FOR HIGH-RISK MYELOFIBROSIS | 日本新薬株式会社 | 2023-09-21 | — | — | WO | disclosed |
| WO-2023175932-A1 | THERAPEUTIC AGENT FOR HIGH-RISK MYELOFIBROSIS | 日本新薬株式会社 | 2023-09-21 | — | — | WO | disclosed |
| WO-2022239068-A1 | CYTOKINE STORM INHIBITOR | 日本新薬株式会社 | 2022-11-17 | — | — | WO | disclosed |