SCHEMBL30011189

SCHEMBL30011189

Cc1cn(-c2cc(NC(=O)c3ccc(C)c(C#Cc4cnc5cccnn45)c3)cc(C(F)(F)F)c2)cn1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ABL1 P00519 19/20 1.00
BCR P11274 4/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16644581 1.00 ABL1 (1.00) ABL1BCR
SCHEMBL30788435 0.94 ABL1 (0.88) ABL1
SCHEMBL30788443 0.94 ABL1 (0.88) ABL1
SCHEMBL30788449 0.93 ABL1 (0.87) ABL1BCR
SCHEMBL15442784 0.93 ABL1 (0.87) ABL1BCR
SCHEMBL24123159 0.92 ABL1 (1.00) ABL1BCR
SCHEMBL30011770 0.92 ABL1 (1.00) ABL1
SCHEMBL24123283 0.92 ABL1 (1.00) ABL1BCR
SCHEMBL30011137 0.92 ABL1 (1.00) ABL1BCR
SCHEMBL30010951 0.92 ABL1 (1.00) ABL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4580617-A2 SMALL MOLECULE INHIBITORS OF BCR-ABL Oregon Health & Science University (US) 2025-07-09 EP disclosed
CN-120018845-A Small molecule inhibitors of BCR-ABL 俄勒冈健康与科学大学 2025-05-16 CN disclosed
WO-2024049854-A2 SMALL MOLECULE INHIBITORS OF BCR-ABL OREGON HEALTH & SCIENCE UNIVERSITY (US) 2024-03-07 WO disclosed
EP-4326269-A1 COMPOUNDS WITH IMPROVED CARDIAC SAFETY FOR THE TREATMENT OF CANCER AND NEURODEGENERATIVE DISORDERS Oregon Health & Science University (US) 2024-02-28 EP disclosed
WO-2022225972-A1 COMPOUNDS WITH IMPROVED CARDIAC SAFETY FOR THE TREATMENT OF CANCER AND NEURODEGENERATIVE DISORDERS OREGON HEALTH & SCIENCE UNIVERSITY (US) 2022-10-27 WO disclosed