Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 6/20 | 0.56 |
| ▸ | RAB9A | P51151 | 7/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 6/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3001287 | 1.00 | MAPKAPK2 (0.56) | MAPKAPK2RAB9ASMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL2997854 | 0.92 | MAPKAPK2 (0.56) | MAPKAPK2RAB9ASMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL2997857 | 0.92 | MAPKAPK2 (0.56) | MAPKAPK2RAB9ASMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL2987172 | 0.90 | MAPKAPK2 (0.54) | MAPKAPK2RAB9ASMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL2987173 | 0.90 | MAPKAPK2 (0.54) | MAPKAPK2RAB9ASMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL2999603 | 0.87 | MAPKAPK2 (0.59) | MAPKAPK2RAB9ASMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL13268193 | 0.86 | MAPKAPK2 (0.56) | MAPKAPK2RAB9ASMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL3004600 | 0.81 | MAPKAPK2 (0.65) | MAPKAPK2RAB9ASMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL3000940 | 0.81 | MAPKAPK2 (0.56) | MAPKAPK2MAPK1ALDH1A1NPC1MAPT | |
| SCHEMBL3000941 | 0.81 | MAPKAPK2 (0.56) | MAPKAPK2MAPK1ALDH1A1NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100190773-A1 | Anti-Cytokine Heterocyclic Compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-07-29 | — | — | US | disclosed |
| US-20100190773-A1 | Anti-Cytokine Heterocyclic Compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-07-29 | — | — | US | disclosed |
| US-20060276496-A1 | Anti-Cytokine Heterocyclic Compounds | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2006-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276496-A1 | Anti-Cytokine Heterocyclic Compounds | MAPKAPK2, MAP4K2, MAP3K2 | MAPKAPK2 1/4885RAB9A 1982/4885SMN1; SMN2 3033/4885 |
| US-20100190773-A1 | Anti-Cytokine Heterocyclic Compounds | MAPKAPK2, MAP4K2, MAP3K2 | MAPKAPK2 1/4885RAB9A 1982/4885SMN1; SMN2 3033/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.