Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 20/20 | 0.38 |
| ▸ | DNER | Q8NFT8 | 2/20 | 0.37 |
| ▸ | BRDT | Q58F21 | 4/20 | 0.36 |
| ▸ | BRD2 | P25440 | 3/20 | 0.36 |
| ▸ | BRD3 | Q15059 | 3/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | BRD1 | O95696 | 1/20 | 0.36 |
| ▸ | CCL2 | P13500 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | EP300 | Q09472 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19986334 | 0.83 | BRD4 (0.40) | BRD4DNERADORA3TSPO | |
| SCHEMBL31498747 | 0.81 | BRD4 (0.45) | BRD4DNERADORA3TSPO | |
| SCHEMBL18979672 | 0.80 | BRD4 (0.46) | BRD4DNERBRD2ADORA3TSPO | |
| SCHEMBL17165522 | 0.80 | BRD4 (0.46) | BRD4DNERBRD2ADORA3TSPO | |
| SCHEMBL31498729 | 0.78 | BRD4 (0.45) | BRD4DNERBRDTBRD2BRD3 | |
| SCHEMBL872054 | 0.77 | BRD4 (0.58) | BRD4DNERBRDTBRD2BRD3 | |
| SCHEMBL18551067 | 0.77 | BRD4 (0.58) | BRD4DNERBRDTBRD2BRD3 | |
| SCHEMBL17165553 | 0.75 | BRD4 (0.43) | BRD4DNERBRDTBRD2BRD3 | |
| SCHEMBL17165549 | 0.75 | BRD4 (0.43) | BRD4DNERBRDTBRD2BRD3 | |
| SCHEMBL23348743 | 0.75 | CHRM1 (0.43) | BRD4DNERADORA3TSPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022221786-A2 | COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THAT MODULATE BRD4 | Plexium, Inc. (US) | 2022-10-20 | — | — | WO | disclosed |